Metronidazole Infusion 100ml Plastic Bottle

• Customization: Available
• Application: Internal Medicine
• Usage Mode: Infusion
• Model NO.: 100ml
• State: Liquid
• Shape: Infusion
• Type: Inorganic Chemicals
• Pharmaceutical Technology: Chemical Synthesis
• Transport Package: Carton
• Specification: 100ml/box, 80boxes/carton
• Trademark: SHIMEN
• Origin: China
• HS Code: 3004909099
• Production Capacity: 1000000

Product Description

Metronidazole

Name: Metronidazole Injection(100ml:500mg)
Structural formula: C₆H₉N₃O₃
Description the product is colorless or almost colorless pellucid liquid.
Pharmacokinetics
The peak value is observed 20mins after administering by intravenous drip and binding rate with protein <5%. After absorption Metronidazole distributes widely in all kinds of tissues and body liquids, and pass easily blood brain barrier to the tissues such as saliva, placenta, bile, latex, ammiotic fluid, semen, urine, purulence, cerebrospinal fluid and etc. It is reported that the concentration in placenta, latex, bile is similar with that in plasma.
For the healthy people the concentration of Metronidazole in the cerebrospinal fluid is about 43% of that in the plasma, and the effective concentration can remain 12hours. 60~80% of the  preparation is excreted via kidney, about 20% of Metronidazole is excreted unchanged in the urine, the other is excreted in the urine as the products of metabolism (25%- glucuronicacid combo, 14%-other kinds of products of metabolism). 10% of Metronidazole is excreted in the dejection, and 14% is excreted from skin.
Disease treated Metronidazole is mainly used in the treatment of anaerobe bacterial infection.
Administration and dosage By drip phleboclysis.1. doses for the adult In the treatment of anaerobic bacteria infections, administer by intravenous drip according to 1g/70kg for the first time, and calculate the does according to 7.5mg/kg  during the course of treatment, and interval time is 6~8hours.
2. doses for the children In the treatment of anaerobic bacteria infection, the doses are similar with that of the adult.
Side-effect 15~30% of the cases were reported side-effect, and adverse reactions frequently associated with Metronidazole include: digestive tract reaction such as nausea, vomiting, and diarrhea stomach pain or cramps, anorexia; symptoms of nerve system include headache and swirl; abnormal sensation, numb limbs and tense tendons , ataxia, and multiple neuritis occasionally happen; over high dose can cause convulsion. Few cases have the symptoms such as urticaria,moisst, pruritus, cystitis, dysuresia, change in taste sensation and decreased white cell. But the abovementioned symptoms are all reversible and recover after the administration.
Contraindication
Forbid to use the medicine for the patients with the diseases in central nervous system and flood.
Attention
(1)the product has potential factors of cancer for some animals
(2)Interfere with the diagnosis: metabolic products of the medicine can make the urine carmine.
(3)Less dosage should be administered for the patients with diseases of liver and viscera. Stop using the product if the symptoms such as ataxia or other central nerve system exit. Record the amount of white cell before the repeated course of the treatment. For the patients with anaerobe bacteria infection complicated with renal failure, the administration interval should be prolonged from 8hours to 12hours.
(4)the product can inhibit the metabolism of alcohol, so during the course of treatment forbid to drink, or stomachache, vomiting and headache may be shown.
Indication for women in pregnant and suckle
Forbid to use this medicine for women in pregnant and suckle.
Substance interactions
Metronidazole may increase the effects of Warfarin anticoagulants.
Overdose High dose may cause convulsion.