| Customization: | Available |
|---|---|
| Application: | Internal Medicine |
| Usage Mode: | Injection |
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Pharmacology and Toxicology
Sodium and chlorine are important electrolytes in the body, mainly in the extracellular fluid, and play a very important role in maintaining the body's normal blood and extracellular fluid volume and osmotic pressure. The normal serum sodium concentration is 135~145m mol/L, accounting for 92% of plasma cations and 90% of the total osmotic pressure. Therefore, the amount of plasma sodium plays a decisive role in osmotic pressure. The normal serum chlorine concentration is 98~106m mol/L. The human body is mainly regulated by the hypothalamus, posterior pituitary gland and kidney to maintain the stability of body fluid volume and osmotic pressure.
Pharmacokinetics
In the gastrointestinal tract, sodium is almost completely absorbed through the active transport of intestinal mucosal cells. Sodium is mainly excreted by the kidneys.
Indications
1. Water loss caused by various reasons, including hypotonicity, isotonicity and hypertonicity.
2. In hypertonic nonketotic coma, the application of isotonic or hypotonic sodium chloride can correct dehydration and hypertonic state.
3. Low-chlorine metabolic alkalosis.
4. Externally use normal saline to flush eyes and wash wounds.
5. Water bladder for obstetrics to induce labor.
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